Thesis work: Synthesis of mono- and bicyclic linkers for peptides.


Kerstin Karlsson,
Application deadline:
Job type:
full time
Type of employment:
Västra Götalands län, 
Mölndal kommun
Life Science
Läkemedel, bioteknik & medicinteknik

Job description.

Curious chemistry student with passion for lab work
Would you like to work with organic synthesis applied to peptides? We are looking for a curious person with passion for chemistry that like to try out ideas in the lab. 

Thesis work 30 credits
AstraZeneca is looking for a curious chemistry student with passion for lab work for a 30 credits thesis project. The work will be unpaid but in the end the student will receive a gratuity of 20,000 SEK when the thesis is approved.

Medicinal Chemistry, RIA, Gothenburg

AstraZeneca is a major pharmaceutical company in the Gothenburg region. The work will be performed in the New Modality Group at Medicinal Chemistry within the Early Respiratory, Inflammation and Autoimmunity (RIA) disease area. Our group works with state-of-the-art synthesis of oligonucleotides and peptides and has got eight permanent members.


AstraZeneca is seeking a person who would like to help them expand their toolbox of linkers for mono- and bicyclic peptides. This will include linker synthesis and application of them to peptides to see if it is possible to form the cycles envisioned. The work will be performed on non-project related compounds so as to enable disclosure and publication later on.

The work will be lab oriented and AstraZeneca's labs are well-equipped in terms of synthesis machines and fume hoods. You will be working with techniques such as solid phase peptide synthesis, chromatography, and for analysis NMR spectroscopy and LCMS will be used. A great emphasis will be put on thorough documentation of the work. Collaboration and sharing of experiences and knowledge is a key element within our group.


Essential Requirements
  • Experience of lab based practical organic chemistry
  • Collaborative and open personality – a good team player 
  • Familiar with drawing and interpreting atom based chemical structures on a computer (not just letter codes and acronyms)
  • Experience of NMR spectroscopy
  • Experience of purification of organic compounds (crystallization, flash chromatography, HPLC etc)

Desirable Requirements 
  • Experience of peptide chemistry (preferably SPPS)
  • Experience of LCMS


Deadline for application: 2019-11-17, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.

 For more information: Kerstin Karlsson or Eleonor Ehrman +4673-343 41 09.

Key terms: monocyclic & bicyclic linker, organic synthesis, peptide synthesis, cyclization, purification. Curious chemistry student with passion for lab work

about AstraZeneca.

At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.