AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity.
Early Research and Development Cardiovascular, Renal and Metabolism (Early CVRM) is one of the main therapeutic research areas within BioPharmaceuticals R&D which deliver candidate drugs into late-stage clinical development. This role in Early CVRM is based in AstraZeneca’s world-class vibrant R&D center, located in Gothenburg, Sweden. Early CVRM DMPK interacts with other functions in supporting CVRM projects all along the value chain, from target selection all the way to market launch and Life cycle management.
Now we are looking for a bioanalytical scientist with good knowledge in the area of quantitative bioanalysis of drugs and drug metabolites to join our team in the DMPK department for a consultant assignment. The team you will be part of is focusing on pharmacokinetics, biodistribution and disposition of small molecule, conjugated peptide and nucleotide drug candidates. You will have the opportunity to contribute to the discovery of new life changing medicines for patients and demonstrate and witness what science can do.
You will be responsible for analysing drug candidates and their metabolites in various in vitro and in vivo samples including plasma, tissue, and bile samples as well as sub-cellular fractions.
Your responsibility will include delivering quality in vitro and in vivo bioanalytical data including analysis of drugs, drug candidates and drug metabolites in various in vitro and in vivo samples to support PKPD (Pharmacokinetics and Pharmacodynamics) work in projects from target selection to LCM (life cycle management). The data generated is mainly aimed to provide insight to quantitative pharmacology as well as to right tissue and right exposure aspects, including the fates of drugs and their metabolites.
This laboratory based scientific role includes developing and validating methods to enable delivery of data with the necessary quality and scientific information aligned with the project needs. The role requires interactive, effective communication to provide clear data and guidance to project representatives, act as an example to other scientists, and contribute to the overall team delivery. It will require making judgements about bioanalysis information, developing innovative solutions and applying cross-disciplinary understanding.
Minimum requirements and key factors
- M.Sc or equivalent degree in a relevant discipline is required (e.g analytical chemistry, biochemistry, biotechnology or pharmacy)
- Good knowledge of liquid chromatography and mass spectrometry ionization and detection (LC-MS/MS) and bioanalytical work in Drug Discovery & Development
- Track record of delivering state-of-the-art bioanalysis data to projects in discovery and/or development setting is a clear advantage
- Basic understanding of DMPK
- Understanding of the overall drug discovery and development process
- Good communication skills in English, both verbal and in writing are required
- Demonstrated ability to work in team and independently
2019-12-05, selection and interviews will be ongoing. The position may be filled before the last day of application, therefore, apply as soon as possible.
For more information: Eleonor Ehrman, Consultant manager +4673-343 41 09 or Kerstin Karlsson, Consultant manager +4673-084 86 95.
about Randstad Life Sciences.
Randstad Life Sciences specializes in the field of science and is part of Randstad, the world leader in recruitment and consulting with operations in 38 countries. With this global network, in combination with our strong local foundation, we can offer a wide range of varied and developing assignments and jobs for you who are a specialist in life science. Our mission is to help you reach your true potential with your career in focus!